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Title   폐의 편평상피세포암에서 신생혈관형성과 Matrix Metalloproteinase의 예후인자로서의 가치 평가에 관한 연구 ( Evaulation of Angiogenesis and Matrix Metalloproteinase as Pregnostic Markers in Squamous Cell Carcinoma of the Lung )
Publicationinfo   1997 Jan; 029(05): 816-825.
Key_word   Lung cancer, Angiogenesis, MMP-1, MMP-2
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Abstract   Purpose: In squamous cell carcinomas of the lung, the angiogenesis and the expression rates of metalloproteinase were measured to examine whether they can be useful as prognostic markers and therapeutic potentials. Materials and Methods: The angiogenesis and the expression rates of metalloproteinase were analyzed by counting the number of microvessels and immunohistochemically positive cells of MMP-1 and MMP-2 in 54 squamous cell carcinoma, respectively. Results: Lymph node meatastasis group showed higher angiogenesis than non-metastasis one(p=0.008). Angiogenesis were elevated with increasing clinical stage. However, MMP-1 and MMP-2 expression rate as the presence or absence of lymph node metastasis and the clinical stages were statistically insignificant, respectively. Angiogenesis failed to demonstrate any significant correlation with the expression rates of MMPs. Conclusion: Our results suggests that angiogenesis level may provide informaton relevant to prognosis as well as treatment decisions.
저 자   김영식(Young Sik Kim),김영배(Young Bae Kim),신동환(Dong Hwan Shin),김한겸(Han Kyum Kim),염범우(Bum Woo Yum),최종상(Jong Sang Choi)김인선(In Sun Kim),이대일(Dae Il Lee),